Ohnologs (Database)[edit]

Ohnologs is a repository of the genes retained by the two rounds of whole genome duplications in six vertebrate genomes. The vertebrates currently included in Ohnologs are human, mouse, rat, chicken, pig and dog. The ohnolog pairs and families have been constructed using a quantitative multiple-genome comparative approach^[1].

Importance of ohnologs[edit]

The genes retained from whole genome duplications are called ohnologs, after Susumu Ohno who proposed the importance of whole genome duplications in vertebrate evolution. Ohnologs in the human genome are known to be dosage balanced^[2], and are frequently associated with cancers^[3], dominant genetic diseases^[4]^[5], and pathogenic copy number mutations^[6].

References[edit]

^ Singh, Param Priya; Arora, Jatin; Isambert, Hervé (2015-7). "Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes". PLoS computational biology. 11 (7): e1004394. doi:10.1371/journal.pcbi.1004394. ISSN 1553-7358. PMC 4504502. PMID 26181593. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
^ Makino, Takashi; McLysaght, Aoife (2010-05-18). "Ohnologs in the human genome are dosage balanced and frequently associated with disease". Proceedings of the National Academy of Sciences of the United States of America. 107 (20): 9270–9274. doi:10.1073/pnas.0914697107. ISSN 1091-6490. PMC 2889102. PMID 20439718.{{cite journal}}: CS1 maint: PMC format (link)
^ Singh, Param Priya; Affeldt, Séverine; Cascone, Ilaria; Selimoglu, Rasim; Camonis, Jacques; Isambert, Hervé (2012-11-29). "On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates". Cell Reports. 2 (5): 1387–1398. doi:10.1016/j.celrep.2012.09.034. ISSN 2211-1247. PMID 23168259.
^ Malaguti, Giulia; Singh, Param Priya; Isambert, Hervé (2014-5). "On the retention of gene duplicates prone to dominant deleterious mutations". Theoretical Population Biology. 93: 38–51. doi:10.1016/j.tpb.2014.01.004. ISSN 1096-0325. PMID 24530892. {{cite journal}}: Check date values in: |date= (help)
^ Singh, Param Priya; Affeldt, Séverine; Malaguti, Giulia; Isambert, Hervé (2014-7). "Human dominant disease genes are enriched in paralogs originating from whole genome duplication". PLoS computational biology. 10 (7): e1003754. doi:10.1371/journal.pcbi.1003754. ISSN 1553-7358. PMC 4117431. PMID 25080083. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
^ McLysaght, Aoife; Makino, Takashi; Grayton, Hannah M.; Tropeano, Maria; Mitchell, Kevin J.; Vassos, Evangelos; Collier, David A. (2014-01-07). "Ohnologs are overrepresented in pathogenic copy number mutations". Proceedings of the National Academy of Sciences of the United States of America. 111 (1): 361–366. doi:10.1073/pnas.1309324111. ISSN 1091-6490. PMC 3890797. PMID 24368850.{{cite journal}}: CS1 maint: PMC format (link)

[1] Singh, Param Priya; Arora, Jatin; Isambert, Hervé (2015-7). "Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes". PLoS computational biology. 11 (7): e1004394. doi:10.1371/journal.pcbi.1004394. ISSN 1553-7358. PMC 4504502. PMID 26181593. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

[2] Makino, Takashi; McLysaght, Aoife (2010-05-18). "Ohnologs in the human genome are dosage balanced and frequently associated with disease". Proceedings of the National Academy of Sciences of the United States of America. 107 (20): 9270–9274. doi:10.1073/pnas.0914697107. ISSN 1091-6490. PMC 2889102. PMID 20439718.{{cite journal}}: CS1 maint: PMC format (link)

[3] Singh, Param Priya; Affeldt, Séverine; Cascone, Ilaria; Selimoglu, Rasim; Camonis, Jacques; Isambert, Hervé (2012-11-29). "On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates". Cell Reports. 2 (5): 1387–1398. doi:10.1016/j.celrep.2012.09.034. ISSN 2211-1247. PMID 23168259.

[4] Malaguti, Giulia; Singh, Param Priya; Isambert, Hervé (2014-5). "On the retention of gene duplicates prone to dominant deleterious mutations". Theoretical Population Biology. 93: 38–51. doi:10.1016/j.tpb.2014.01.004. ISSN 1096-0325. PMID 24530892. {{cite journal}}: Check date values in: |date= (help)

[5] Singh, Param Priya; Affeldt, Séverine; Malaguti, Giulia; Isambert, Hervé (2014-7). "Human dominant disease genes are enriched in paralogs originating from whole genome duplication". PLoS computational biology. 10 (7): e1003754. doi:10.1371/journal.pcbi.1003754. ISSN 1553-7358. PMC 4117431. PMID 25080083. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

[6] McLysaght, Aoife; Makino, Takashi; Grayton, Hannah M.; Tropeano, Maria; Mitchell, Kevin J.; Vassos, Evangelos; Collier, David A. (2014-01-07). "Ohnologs are overrepresented in pathogenic copy number mutations". Proceedings of the National Academy of Sciences of the United States of America. 111 (1): 361–366. doi:10.1073/pnas.1309324111. ISSN 1091-6490. PMC 3890797. PMID 24368850.{{cite journal}}: CS1 maint: PMC format (link)

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